Fri Jan 27 2023

36 articles - From Friday Jan 20 2023 to Friday Jan 27 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

J Crohns Colitis

Systematic review with meta-analysis: The impact of cancer treatments on the disease activity of inflammatory bowel diseases.

Current data indicate a high proportion of patients with IBD experiencing a flare following the start of cancer treatment. Patients with IBD were at increased risk of gastrointestinal toxicity following ICI treatment compared to those without IBD. However, cancer therapy-induced IBD flares were manageable and should not preclude appropriate cancer treatments.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Inflamm Bowel Dis

Early Life Stress in Mice Leads to Impaired Colonic Corticosterone Production and Prolonged Inflammation Following Induction of Colitis.

Our study identifies impaired local glucocorticoid production and responsiveness as a potential mechanism whereby ELS predisposes to chronic colitis in susceptible hosts.

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Epicutaneous Immunotherapy with CBir1 Alleviates Intestinal Inflammation.

Epicutaneous immunotherapy with MEP1 induced Tregs that migrate to intestines and suppress inflammation in mice with CBir1 or A4Fla2-positive bacterial colonization. This could be a potential strategy to treat CD and warrants further study.

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Histologic Predictors of Clinical Outcomes and Healthcare Utilization in Patients With Ileal Pouch-Anal Anastomosis.

Histologic findings may be predictive of IPAA outcomes. Pathologists should incorporate key histologic variables into pouchoscopy pathology reports. Clinicians may need to more closely monitor IPAA patients with significant histologic findings.

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Inflammatory Bowel Disease Among Canadian Children: Comparison Between Children of Non-European Descent and Children of European Descent.

Important differences exist between different ancestral groups in pediatric patients with IBD with regard to age of diagnosis, family history, and immigrant status. Our study adds to the knowledge of the impact of ancestry on IBD pathogenesis.

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Inhibition of Soluble Stem Cell Factor Promotes Intestinal Mucosal Repair.

These data demonstrate that SCF functions as a pro-inflammatory mediator in mucosal tissues and that specific neutralization of SCF248 could be a viable therapeutic option to reduce intestinal inflammation and promote mucosal wound repair in individuals with IBD.

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Preoperative Simulation of Ileal Pouch-Anal Anastomosis in Patients With Ulcerative Colitis Using a 3-Dimensional Printed Model.

We established a method for creating 3D deformable models of patients with ileal pouch-anal anastomosis. These 3D models may be useful for preoperative simulation.

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Risk Variants in or Near ZBTB40 AND NFATC1 Increase the Risk of Both IBD and Adverse Bone Health Outcomes Highlighting Common Genetic Underpinnings Across Both Diseases.

Patients with IBD are at increased risk for low bone density, independent of steroid use. Variants in or near ZBTB40 and NFATC1 are associated with an increased risk of IBD and low bone density.

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Serum Lipidomic Screen Identifies Key Metabolites, Pathways, and Disease Classifiers in Crohn's Disease.

Untargeted lipidomic analyses uncovered perturbations in the circulating human CD lipidome, likely resulting from multiple pathogenic mechanisms. Models using as few as 5 biomarkers had strong disease classifier characteristics, supporting their potential use in diagnosis or prognosis.

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STING Promotes Intestinal IgA Production by Regulating Acetate-producing Bacteria to Maintain Host-microbiota Mutualism.

STING promotes intestinal IgA by regulating acetate-producing gut bacteria.

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Sweets and Inflammatory Bowel Disease: Patients Favor Artificial Sweeteners and Diet Foods/Drinks Over Table Sugar and Consume Less Fruits/Vegetables.

Consumption of artificial sweeteners correlated with healthy habits, suggesting that our IBD population deemed artificial sweeteners as healthy and/or had preferences for naturally or artificially sweetened flavors and products.

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The Prevalence of Inflammatory Bowel Disease in Greenland.

This study estimates the prevalence and uncovers characteristics of IBD in Greenland. Although CD may be underdiagnosed or less prevalent, the overall prevalence of IBD in Greenland parallels Scandinavian countries and North America. These results boost the knowledge on autoimmune diseases in arctic populations and may guide clinicians in their management of IBD in Greenland. Furthermore, the results may encourage research in IBD across the Arctic regions.

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J Crohns Colitis

A compendium of mucosal molecular characteristics provides novel perspectives on the treatment of ulcerative colitis.

We conducted a deep stratification of mucosal tissue using the most comprehensive microarray and RNA sequencing data, providing critical insights into pathophysiological features of UC, which could serve as a template for stratified treatment approaches.

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A model-based tool for guiding infliximab induction dosing to maximise long-term deep remission in children with inflammatory bowel diseases.

A freely available, multi-model MIPD tool facilitates infliximab induction dosing and improves deep remission rates in children with IBD.

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GATA6-AS1 regulates intestinal epithelial mitochondrial functions, and its reduced expression is linked to intestinal inflammation and less favorable disease course in ulcerative colitis (UC).

GATA6-AS1 levels are reduced in UC, CD, and celiac, and in more severe UC forms. We highlight GATA6-AS1 as a target regulating epithelial mitochondrial functions, potentially through controlling TGM2 levels.

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Pathogenesis of Perianal Fistulizing Crohn's Disease: Current knowledge, gaps in understanding and future research directions.

In the end, we discussed future directions in basic, translational, and clinical research that may dramatically improve our understanding of perianal Crohn's disease and open avenues for novel therapeutic strategies with a multidisciplinary approach. Overall, this review aims to identify current gaps in perianal fistulizing Crohn's disease and explore future research priorities for this debilitating condition.

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Rescue therapies for steroid-refractory acute severe ulcerative colitis: A review.

Although cyclosporine and infliximab still represent the mainstays of salvage therapy for steroid-refractory ASUC, new therapeutic agents may also play a role. Tofacitinib, due to its rapid effect, is an attractive therapeutic rescue option. Vedolizumab and ustekinumab, as maintenance therapy in combination with the fast-acting cyclosporine as induction therapy, may represent a promising bridging strategy, especially in patients with previous failure to thiopurines and/or anti-TNF agents.

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Serum N-Glycomic Biomarkers Predict Treatment Escalation in Inflammatory Bowel Disease.

Application to an independent replication cohort of 54 IBD patients yielded a HR of 5.1 (p=1.1×10-5; 95% CI, 2.54-10.1). These data demonstrate the prognostic capacity of serum N-glycan biomarkers and represent a step towards personalized medicine in IBD.

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Thioguanine is effective as maintenance therapy for inflammatory bowel disease: a prospective multicentre registry study.

Sustained corticosteroid-free clinical remission over 12 months was achieved in 45% of IBD patients on monotherapy with thioguanine. A drug continuation rate of 80%, together with favourable PGA and QoL scores, underlines the tolerability and effectiveness of thioguanine for IBD.

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Vaccines in children exposed to biological agents in utero and/or during breastfeeding: are they effective and safe?

Vaccines seems to be effective in infants exposed to biologics in utero. Inactivated vaccines are probably safe, whereas live-attenuated vaccines should be avoided while the children have detectable levels of biological drugs. Vaccines (non-live and live) are probably safe in children breastfed by mothers treated with biologics.

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Liver Transpl

Bacteriascites confers poor patient prognosis beyond MELD prediction.

BA has a negative impact on patient survival above that predicted by the MELD score. It has similar impact to SBP on patient survival beyond 1-month suggesting it should be seen as a poor prognostic marker and prompt consideration of LT where appropriate. Further studies evaluating the role of secondary prophylaxis in this group are required.

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Digital Imaging Software vs. the "Eyeball" Method in Quantifying Steatosis in a Liver Biopsy.

DIS provides reproducible quantification of steatosis that could standardize MaS definitions and identify phenotypes associated with good clinical outcomes to increase utilization of steatotic livers.

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Pre-transplant mycophenolate mofetil may be associated with reduced intrahepatic cholangiopathy in ABO-incompatible liver transplantation.

Transplantations involving a donor who underwent laparoscopic donor surgery and a recipient who received pre-transplant mycophenolate mofetil resulted in no increased risk compared to transplantations from donors who underwent open surgery. (HR=5.307, CI=0.315-89.366, P=0.25) Laparoscopic donor hepatectomy was a risk factor for intrahepatic cholangiopathy in ABO-incompatible liver transplantation while pre-transplant mycophenolate mofetil was related to risk reduction of intrahepatic cholangiopathy.

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Six-Minute walk distance predicts outcomes in liver transplant candidates.

In conclusion, shorter 6MWD is associated with increased risk of death, hospitalizations, and worse quality of life in patients evaluated for liver transplantation. 6MWD may be a useful adjunct for risk-assessment in patients undergoing liver transplant evaluation.

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Three-year results of renal function in liver transplant recipients on low-dose sirolimus and tacrolimus: a multicenter, randomized, controlled trial.

No differences in the secondary endpoints and the number of serious adverse events were found between the groups. Once daily low-dose SRL combined with low-dose extended-release TAC does ultimately not provide less CKD grade =3 at 36 months compared to normal-dose extended-release TAC.

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Pancreatology

Increased incidence of positive peritoneal lavage cytology early after fine needle aspiration in patients with pancreatic ducal adenocarcinoma.

A short interval between FNA and CY examination for a large tumor may be a risk factor for CY+ in patients with left-sided PDAC.

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Metanalyses on metformin's role in pancreatic cancer suffer from severe bias and low data quality - An umbrella review.

Meta-analyses describing the association of metformin use in patients with pancreatic cancer are plagued by various types of bias inherent in retrospective studies. The quality of evidence linking metformin to decreased pancreatic cancer mortality is generally low.

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Plasma renalase levels are associated with the development of acute pancreatitis.

Low plasma acidified RNLS levels, and increased native RNLS levels are associated with AP. Additional studies should assess the clinical correlation between plasma RNLS levels and AP severity and outcomes.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

J Crohns Colitis

Genetic evidence for causal relationship between body mass index and inflammatory bowel disease: a Mendelian randomisation study.

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Liver Transpl

Assessment of liver graft steatosis: a new panorama.

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Is stenting really necessary during primary angioplasty for portal vein stenosis after pediatric liver transplantation?

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Liver transplant at all costs.

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Long-term instead of repetitive treatment: benefits of primary stenting for portal vein stenosis in pediatric liver transplantation.

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Navigating the road to liver transplantation equity.

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Salvaging the Fatty Liver for Transplant- Is Short Duration NMP Enough?

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When worlds collide.

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Letters&Replies

Letters to the editors and authors’ replies